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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Clostridium perfringens beta toxin ： ウィキペディア英語版 Clostridium perfringens beta toxin ''Clostridium perfringens'' beta toxin is one of the four major lethal toxins produced by ''Clostridium perfringens'' Type B and Type C strains. It is a necrotizing agent and it induces hypertension by release of catecholamine. It has been shown to cause necrotic enteritis in mammals and induces necrotizing intestinal lesions in the rabbit ileal loop model. ''C. perfringens'' beta toxin is susceptible to breakdown by proteolytic enzymes, particularly trypsin. Beta toxin is therefore highly lethal to infant mammals because of trypsin inhibitors present in the colostrum.〔 ==Structure & Homology== ''Clostridium perfringens'' beta toxin shows significant genetic homology with several other toxins. ''C. perfringens'' beta toxin shows 28% homology with ''S. aureus'' alpha toxin and similar homology to ''S. aureus'' gamma-toxin and leukocidin. It appears in two forms. The smaller, with a molecular mass of 34 kDa, represents the monomeric gene product. The larger has a molecular mass of 118 kDa and may be an oligomer of smaller units. The first 27 amino acids may encode a signal that allows beta toxin to cross the cell membrane, further evidenced by the presence of beta toxin in extracellular fluid of ''C. perfringens'' cultures.〔Hunter, S.E., J.E. Brown, P.E. Oyston, J. Sakurai, & R.W. Titball. 1993. Molecular genetic analysis of beta-toxin of ''Clostridium perfringens'' reveals sequence homology with alpha-toxin, gamma-toxin, and leukocidin of ''Staphylococcus aureus''. Infection and Immunity. 61(9): 3958-3965.〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Clostridium perfringens beta toxin」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.